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Yet, controversial outcomes on the efficacy of metformin have also been reported 21,22,23,24 , that might be attributed to heterogeneity of responses in some patient subgroups

Furthermore, the treatment was well-tolerated, with good overall compliance

Rapid closure of the follicular wound, through the migration and proliferation of epithelial cells, is crucial for restoring the barrier function, which is essential for protecting the body

Then, they were rinsed with phosphate buffered saline (PBS), sealed with buffered glycerol, and finally observed under fluorescence microscopy

Mechanical studies have shown that TET2 inhibits ferroptosis via demethylation of the GPX45 promoter 118